Pippali (Piper longum) Part 2
Pippali ( Piper longum ) Part 2 Modern View Piperine Molecular formula: C17H19NO3 Structural formula: Piperine was discovered and isolated in 1819 by Hans Christian Orsted from fruits of black and white pepper. Piperine is also found in Pippali ( Piper longum ). [65] Piperine was first synthesized in 1882. It is an alkaloid. The solubility of piperine in water is 40mg/L. Piperine enhances the bioavailability of vitamins, minerals and curcumin. The mechanism of this activity is still under study. Piperine is known to inhibit the enzymes P-glycoprotein and cytochrome P450 3A4 (abbreviated CYP3A4) in humans. Animal studies also show that piperine inhibits cytochrome P450 (CYP 450) enzymes that metabolize many drugs. Piperine raises levels of dopamine and serotonin. It induces natural sleep and serenity. It enhances memory and recall. It relieves stress. It improves metabolism and helps weight loss. By correcting malfunctioning of immune syste