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Two phytochemicals from Yashtimadhu-Licorice ( Glycyrrhiza glabra ) Dr. Hemant Vinze M.S. Introduction Yashtimadhu-licorice ( Glycyrrhiza glabra ) is rich in pharmacologically active chemicals. In this article I discuss the pharmacology of Glycyrrhizin and Glycyrrhetinic acid. Glycyrrhizin  Molecular formula:  C42H62O16  Structural formula: Glycyrrhizin (or glycyrrhizic acid or glycyrrhizinic acid) is the chief constituent of the root of Yashtimadhu-licorice ( Glycyrrhiza glabra ). It is sweet in taste being 30-50 times sweeter than sucrose (cane sugar). It is a triterpenoid-saponin extracted from the root of the plant and is used as an emulsifier and gel-forming agent in food stuff and cosmetics. Its aglycone is oxolone. Glycyrrhizine has therefore been used as a prodrug for that compound. The content of glycyrrhizin/ glycyrrhizic acid in Yashtimadhu-licorice ( Glycyrrhiza glabra ) root is 2-24 % of the dry weight. [1] ...

Glabridin from Yashtimadhu-Licorice ( Glycyrrhiza glabra ) Dr. Hemant Vinze M. S. Introduction Glabridin displays pleotropic pharmacological activities. It is a key phytochemical found in Yashtimadhu-Licorice ( Glycyrrhiza glabra ). It can be said that all pharmacological activities of Yashtimadhu are due glabridin. In this article I discuss in detail the pharmacology of glabridin. Glabridin Molecular formula:  C20H20O4 Structural formula: Glabridin is an isoflavone, a type of isoflonoid found in the roots of yashtimadhu-licorice ( Glycyrrhiza glabra ). It is a yellowish-brown powder, insoluble in water but soluble in organic solvents such as propylene glycol. It is a hydrophobic chemical. Glabridin improves the functions of mitochondria. Glabridin stimulates DNA synthesis in human endothelial cells. Glabridin has bi-phasic effect on proliferation of human vascular smooth muscle. It is a natural skin lightener having no longterm sid...