Neem ( Azadirachta indica ) Introduction Neem ( Azadirachta indica) is an omnipotent and sacred gift of nature to humankind. The wisdom of use of Neem as a medicinal plant dates back to the ancient Harappa and Mohenjo-Daro civilizations in India. The medical practitioners of that period studied the therapeutic value of Neem tree. The earliest indication of Neem tree being employed for its medicinal properties as a household remedy began nearly 5000 years ago. On the Indian sub-continent the earliest documentation of use of the seeds, oil, bark, leaves and fruit of Neem ( Azadirachta indica) for their medicinal properties dates back to more than 4500 years. In the first millennium BC the Neem tree was called “Sarwa-Roga-Niwaaranee” (= one that could cure all ailments). The ‘Upawanawinoda’ an ancient Sanskrit treaty dealing with forestry and agriculture, describes Neem as a ‘cure’ for ailing soils, plants and livestock. Neem has been widely used in Ayurveda and is also